Gareth Bale is out of Saturday’s Euro 2012 qualifier due to a hamstring injury.
Wales will now face England at the Millennium Stadium minus their 21-year-old winger.
In a statement, the Football Association of Wales said: “Due to a hamstring problem, Gareth Bale has had to withdraw from the Wales squad to face England on Saturday.
“He felt tight last week during training with his club. After playing 90 minutes on Saturday he felt some muscle tightness. Initially, this was expected to be muscle soreness after playing his first game.
“On joining-up with the Welsh squad he was kept off his feet in training for two days to recover. As he still felt tight in the warm-up on Tuesday, Gareth was pulled-out of the session. He did not train at all on Wednesday and was sent for a scan.
“The scan revealed that Gareth Bale picked-up his injury last week.”